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The College Of Chicago This drug is assumed to behave like Acyclovir, is phosphorylated by the viral thymidine kinase, and causes inhibition of DNA synthesis by chain termination. By this means, it is known to inhibit productive MHV-68 replication however does not affect latency. The results are proven beneath those of conventional Southern blots in Fig. 6A. None of the mice that obtained B cells from uninfected mice had proof of MHV-68 infection. Two out of five mice that received cells from contaminated mice had proof of infection in both the spleen and the lungs however not the blood. Thus, in the mice the place transfer had been profitable in establishing infected B cells within the spleen, there was additionally evidence of an infection within the lung. This implies that virus resident in splenic B cells is able to unfold and establish an infection in the lungs. To date, the mode of gammaherpesvirus persistence within the host has been addressed solely with EBV. Only producti